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KMID : 0363319990200010133
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Journal of Korean Oriental Internal Medicine
1999 Volume.20 No. 1 p.133 ~ p.142
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Effects of Scolopendrae corpus on turmor promotion in two-stage carcinogenesis in mice
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Hwang Young-Geun
Yoon Cheol-Ho
Seo Un-Kyo
Kim Jong-Dae
Jung Ji-Chun
Nam Kyung-Soo
Kang Jeong-Jun
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Abstract
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To clarifiy the effects of Scolopendrae corpus(S-C) on turmor promotion in two-stage carcinogenesis in mice was investigated. In vivo system, S-C were seen to gave an inhibitory activity on TPA-induced mouse ear edema. In addition, the S-C were proved to have antitumor-promoting activity in two-stage mouse skin carcinogenesis induced by DMBA and two-stage mouse lung carcinogenesis induced by 4-NQO as a initiator plus TPA and glycerol as a promoter. Moreover, S-C significantly exhibited an cytolytic effect in cells and showed significant antitumor activity against Sarcoma-180 bearing mice by oral administration. These results suggest that S-C could be effective in adjuvant chemotherapy for human cancer.
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KEYWORD
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Scolopendrae corpus, two-stage carcinogenesis
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